头颈部鳞癌最终通常会转移至颈部淋巴结 ,普通病理学检查为阴性的淋巴结可能已发生微转移。微转移的发生率对诊断、治疗及预后判断意义重大 ,故淋巴结转移灶的准确监测至关重要 ,但亚临床阳性淋巴结的监测极为困难。据报道 ,免疫组化染色法的应用已将HE染色法为阴性的乳癌和食? Squamous cell carcinoma of the head and neck usually metastasizes to the cervical lymph nodes. Lymph nodes that are pathologically negative may already have micrometastases. The incidence of micrometastasis is significant for diagnosis, treatment and prognosis, so accurate monitoring of lymph node metastasis is very important, but the monitoring of subclinical positive lymph nodes is extremely difficult. According to reports, the application of immunohistochemical staining has been negative for HE staining and breast cancer.