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目的以肝硬化大鼠为动物模型，研究几种不同药物对大鼠肝脏部分切除术后肝再生的影响。方法ＳＤ大鼠１００只，６０％ＣＣＬ４石腊油混合液（０．３／１００ｇ）皮下注射，４天１次，同时饮用５％酒精溶液，经６８天制成肝硬化动物模型。模型鼠随机分为四组，１４只／组。全麻下均行２／３肝切除术，术后当天按以下方案处理：奥美拉唑组注射０．２ｍｇ／ｋｇ，１次／日；五肽胃泌素组注射０．３ｍｇ／ｋｇ，３次／日；香菇多糖组注射１ｍｇ／ｋｇ，１次／日；对照组注射生理盐水１ｍｇ／ｋｇ。连续给药一周后，每组分别随机取８只大鼠，抽取静脉血样，取下肝脏称重，并制作肝脏标本作光镜，电镜及增殖细胞核抗原（ＰＣＮＡ）检测。二周后，再对每组余下的６只大鼠行同样处理。结果奥美拉唑组及胃泌素组中，血清胃泌素水平增高，与香菇多糖组及对照组比较有统计学意义（Ｐ＜０．０５），胃泌素及奥美拉唑组的再生肝亦有明显增加（Ｐ＜０．０５），但各组间肝功能变化无明显差异。在奥美拉唑组及胃泌素组肝细胞有丝分裂指数（ＭＩ），增殖细胞核抗原（ＰＣＮＡ）阳性染色细胞量明显高于另外两组。光镜检查证实，各组肝脏均有假小叶形成，炎细胞浸润，符合肝硬化病理改变。但Ⅰ、Ⅱ组可见较多双核肝细胞及?
Objective To investigate the effects of several different drugs on liver regeneration after partial hepatectomy in rats with cirrhosis. Methods 100 SD rats were injected subcutaneously with 60% CCL4 paraffin oil (0.3 / 100g) once a day for 4 days, while drinking 5% alcohol solution for 68 days to make animal model of liver cirrhosis. The model rats were randomly divided into four groups, 14 / group. Under general anesthesia were 2/3 liver resection, the day after surgery by the following program: omeprazole group injection 0.2mg / kg, 1 / day; pentagastrin injection 0.3mg / kg, 3 times / day; lentinan injection 1mg / kg, 1 times / day; control group injected with saline 1mg / kg. One week after continuous administration, 8 rats were randomly selected from each group, venous blood samples were taken, the liver was removed and weighed, and liver specimens were made for light microscope, electron microscope and proliferating cell nuclear antigen (PCNA) assay. Two weeks later, the same treatment was performed on the remaining six rats in each group. Results In the omeprazole group and the gastrin group, serum gastrin level was increased, compared with the lentinan group and the control group (P <0.05), while the levels of gastrin and omeprazole There was also a significant increase in regenerative liver (P <0.05), but there was no significant difference in liver function between groups. In the omeprazole group and the gastrin group, the mitotic index (MI) and proliferating cell nuclear antigen (PCNA) positive staining cells were significantly higher than the other two groups. Light microscopy confirmed that each group had false lobule liver formation, inflammatory cell infiltration, in line with the pathological changes of liver cirrhosis. However, more duodenal hepatocytes and?