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目的研究并分析三维适形放疗在食管癌纵膈转移淋巴结治疗中的临床应用效果与安全性,从而为患者提供更为有效、安全的治疗方式。方法将220例食管癌纵膈转移淋巴结患者随机分为观察组和对照组各110例。对照组给予化疗联合常规放疗治疗,观察组在对照组治疗基础上运用三维适形放疗,对比2组临床缓解率、3年生存率和并发症发生率。结果观察组缓解率为87.27%明显高于对照组的68.18%(P<0.05);观察组患者3年生存率为22.73%高于对照组的10.00%(P<0.05);治疗后,观察组患者并发症发生率明显低于对照组(P<0.05)。结论对于食管癌纵膈转移淋巴结患者而言,运用三维适形放疗治疗不仅可有效降低患者放疗的不良反应,且有助于提高患者生存率,值得推广应用。
Objective To study and analyze the clinical application and safety of three-dimensional conformal radiotherapy in the treatment of mediastinal lymph node metastasis in esophageal cancer so as to provide more effective and safe treatment for patients. Methods 220 cases of esophageal cancer mediastinal lymph node metastasis were randomly divided into observation group and control group of 110 cases. The control group received chemotherapy combined with conventional radiotherapy. The observation group was treated with three-dimensional conformal radiotherapy on the basis of the control group. The clinical response rate, 3-year survival rate and complication rate were compared between the two groups. Results The remission rate of the observation group was 87.27%, which was significantly higher than that of the control group (68.18%, P <0.05). The 3-year survival rate was 22.73% in the observation group and 10.00% in the control group (P <0.05) The complication rate of patients was significantly lower than that of control group (P <0.05). Conclusion For patients with mediastinal lymph node metastasis of esophageal cancer, the use of three-dimensional conformal radiotherapy not only can effectively reduce the adverse reactions of radiotherapy, but also help to improve the survival rate of patients, which is worth popularizing and applying.