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目的:观察2%碳酸氢钠含漱液联合氟康唑含漱液治疗慢性阻塞性肺疾病急性加重期患者出现口腔真菌感染的疗效。方法:将60例慢性阻塞性肺疾病急性加重期患者随机分为对照组和观察组各30例,对照组使用氟康唑漱口,观察组在此基础上加用2%碳酸氢钠液含漱,对两组患者预防真菌感染进行疗效观察。结果:观察组患者治疗的有效率显著高于对照组(P<0.05)。结论:2%碳酸氢钠漱口液和用生理盐水与氟康唑配成的漱口液交替含漱疗效优于单纯用氟康唑漱口液,值得临床推广应用。
Objective: To observe the efficacy of 2% sodium bicarbonate gargle combined with fluconazole gargle in the treatment of oral fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods: Sixty patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into control group (30 cases) and observation group (30 cases). Fluconazole was given to mouthwash in the control group. On the basis of the control group, 2% sodium bicarbonate solution Shu, two groups of patients with fungal infection prevention and treatment were observed. Results: The effective rate of treatment in observation group was significantly higher than that in control group (P <0.05). Conclusion: 2% sodium bicarbonate mouthwash and rinse solution with physiological saline and fluconazole are better than those with fluconazole alone, which is worthy of clinical application.