AIM TO report present state of iatrogenic drug-inducedesophageal injury(DIEI)induced by medications in a privateclinic.METHODS:Iatrogenic drug-induced esophageal injury(DIEI)induced by medications has been more frequentlyreported.In a private clinic we encountered 36 cases ofesophageal ulcerations complicating doxycycline therapy ina mainly younger Saudi population(median age 29 years).RESULTS:The most frequent presenting symptoms wereodynophagia,retrosternal burning pain and dysphagia(94 %,75 % and 56 %,respectively).The diagnosis was accordingto medical history and confirmed by endoscopy in all patients.Beside withdrawal of doxycycline,when feasible,all patientswere treated with a proton-pump inhibitor(PPI)and aprokinetic.Thirty patients who reported to the clinic aftertreatment were improved within 1-7(median 1.7)days.CONCLUSION:Esophageal ulceration has to be suspectedin younger patients with odynophagia,retrosternal burningpain and/or dysphagia during the treatment with doxycycline. AIM TO report present state of iatrogenic drug-inducedesophageal injury (DIEI) induced by medications in a private clinic. METHODS: Iatrogenic drug-induced esophageal injury (DIEI) induced by medications has been more frequently reported. In a private clinic we encountered 36 cases of esophageal ulcerations Among them, the most frequent candidates were odynophagia, retrosternal burning pain and dysphagia (94%, 75% and 56%, respectively). The diagnosis was according to medical history and confirmed by endoscopy in all patients. Beside withdrawal of doxycycline, when feasible, all patients treated with a proton-pump inhibitor (PPI) and aprokinetic.Thirty patients who reported to the clinic aftertreatment were improved within 1-7 (median 1.7) days. CONCLUSION : Esophageal ulceration has to be suspected of younger patients with odynophagia, retrosternal burningpain and / or dysphagia during the treatment with doxycyclin e.