目的了解郑州及周边地区住院轻重症手足口病病例流行病学特征及其对比情况,掌握其流行规律,为防治提供依据。方法应用描述性流行病学方法及卡方检验进行分析。结果住院轻症手足口病病例以5～7月份发病率最高,郑州市各县(市)区病例数占66.4%,以4岁以下发病率最高,男女比1.57∶1;住院重症病例以3～8月份发病率最高,男女比1.73∶1,郑州市各县(市)区病例数占71.4%,以3岁以下发病率最高,PE和EV71混合阳性率最高为66.3%,占总阳性数的82.8%。住院手足口病病例1～2岁年龄组发病数最多为615例,占44.4%。结论住院重症病例发病高峰年龄较轻症患儿普遍小1岁左右,发病季节较轻症患儿较早,且持续时间长,男孩发病多于女孩,其中1～2岁年龄段是轻重症手足口病病例共同发病高峰。住院重症手足口病病例主要病原体是EV71型,且多与PE型病原体混合性感染。 Objective To understand the epidemiological characteristics of HFMD and its comparisons in Zhengzhou and surrounding areas and to grasp its epidemic rules and provide basis for prevention and treatment. Methods Descriptive epidemiological methods and chi-square test were used to analyze. Results The incidence of mild hand-foot-mouth disease in hospital was the highest in May-July. The cases in each county (city) of Zhengzhou accounted for 66.4% of cases, with the highest incidence under 4 years old, the ratio of male to female was 1.57:1. ~ August, the highest incidence of male to female ratio of 1.73: 1, Zhengzhou counties (cities) area accounted for 71.4% of cases, with the highest incidence of 3 years of age, PE and EV71 mixed positive rate of 66.3%, the total positive number Of the 82.8%. The incidence of hand-foot-mouth disease in hospitalized patients aged 1-2 years was 615 cases (44.4%). Conclusion The incidence of severe cases of hospitalized patients with mild onset age is generally 1-year-old children with mild onset of the disease earlier and longer duration, the incidence of boys than girls, of which 1 to 2 years of age is severe hand-foot Stomatitis cases co-incidence peak. The main pathogen of hospitalized severe HFMD is EV71 type, and more mixed infection with PE type pathogens.