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中枢神经系统发生耐青霉素金黄色葡萄球菌(金葡菌)感染的发病率和死亡率都较高,新青霉素是治疗严重金葡菌感染的主要药物,但渗入脑脊液(CSF)的资料很少。新青Ⅰ治疗急性细菌性脑膜炎,证明能在不同程度上渗入CSF,但其浓度常低于耐青霉素金葡菌的最小抑菌浓度。新青Ⅲ(Nafcillin)有较强的抗金葡菌作用和对肾脏毒性甚小。本文对经细菌学证实的3例葡萄球菌脑膜炎和6例葡萄球菌败血症不伴脑膜炎病人(其中2
Incidence of penicillin-resistant Staphylococcus aureus (S.aureus) infection in the central nervous system is high, and morbidity and mortality are high. Neonomycin is the major drug for the treatment of severe S. aureus infection, but infiltration into cerebrospinal fluid (CSF) is poorly documented. Iodine Ⅰ treatment of acute bacterial meningitis, proved to varying degrees, into the CSF, but its concentration is often lower than the minimum inhibitory concentration of penicillin-resistant Staphylococcus aureus. Nafcillin has a strong anti-Staphylococcus aureus effect and little toxicity to the kidneys. In this paper, three bacteriologically confirmed staphylococcal meningitis and six staphylococcal septicemia patients without meningitis (of which 2