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目的:探索复方斑蝥胶囊联合化疗用于直肠癌根治术后的临床效果。方法:选取2010年7月—2015年7月期间本院收治的100例直肠癌根治术患者,将患者动态随机化分为两组,两组患者各有50例,对照组和观察组分别采用化疗和复方斑蝥胶囊联合化疗,对比两组患者的T淋巴细胞亚群、常规实验室指标、总有效率、KPS体力恢复情况、不良反应。结果:观察组患者的不良反应(6.00%)、KPS体力改善率(84.00%)、治疗总有效率(98.00%)、血小板(213.61±13.58)×10~9/L、血红蛋白(123.56±5.48)、白细胞(6.23±1.25)×10~9/L、CD4~+/CD8~+水平值(1.98±0.56)g/L、CD8~+水平值(29.47±6.35)%、CD4~+水平值(42.36±3.58)%、CD3~+水平值(65.47±5.69)%明显优于对照组患者的不良反应(26.00%)、KPS体力改善率(60.00%)、治疗总有效率(66.00%)、血小板(156.35±10.32)×10~9/L、血红蛋白(102.36±5.36)、白细胞(3.54±1.36)×10~9/L、CD4~+/CD8~+水平值(1.02±0.69)g/L、CD8~+水平值(27.45±2.69)%、CD4~+水平值(36.25±4.58)%、CD3~+水平值(60.36±4.89)%(P<0.05)。结论:复方斑蝥胶囊联合化疗用于直肠癌根治术后患者中效果显著,且安全性较高。
Objective: To explore the clinical effect of compound cantharidin capsule combined with chemotherapy for rectal cancer after radical operation. Methods: A total of 100 patients undergoing radical resection of rectal cancer who were treated in our hospital from July 2010 to July 2015 were selected. The patients were randomly divided into two groups, 50 patients in each group and control group and observation group Chemotherapy and cantharidin capsules combined with chemotherapy, T lymphocyte subsets, routine laboratory parameters, total effective rate, physical recovery of KPS, and adverse reactions were compared between the two groups. Results: The adverse reactions (6.00%), physical improvement rate of KPS (84.00%), total effective rate of treatment (98.00%), thrombocytopenia (213.61 ± 13.58) × 10 ~ 9 / L and hemoglobin (123.56 ± 5.48) , CD4 ~ + / CD8 ~ + level (1.98 ± 0.56) g / L, CD8 ~ + level (29.47 ± 6.35)% and CD4 ~ + level (6.23 ± 1.25) × 10 ~ 42.36 ± 3.58)%, and the level of CD3 ~ + (65.47 ± 5.69)% was significantly better than that of the control group (26.00%), KPS (60.00%), total effective rate (156.35 ± 10.32) × 10 ~ 9 / L, hemoglobin (102.36 ± 5.36), leukocyte count (3.54 ± 1.36) × 10-9 / L and CD4 + / CD8 + The level of CD8 + was (27.45 ± 2.69)%, the level of CD4 ~ + was 36.25 ± 4.58%, and the level of CD3 + was 60.36 ± 4.89% (P <0.05). Conclusion: The compound cantharidin capsule combined with chemotherapy for rectal cancer after radical surgery in patients with significant effect, and high safety.