据Raison和Standen等的报告,α,ω-双(对烴氨基苯氧基)-烷类化合物(Ⅰ)对于实驗动物感染的三种血吸虫病,都有較高疗效,但这类化合物毒性较大,尤以对视神經有严重的損害.我們改变其化学結构,合成了α,ω-双(对烴氧基苯氨基)-烷类(Ⅱ)及N,N′-双(对取代基苯基)-烴二醯胺(Ⅲ)及烴二酯(Ⅳ)类化合物十四种,以比較化学結构对于疗效和毒性的关系。 According to reports by Raison and Standen et al., Α, ω-bis (para-alkyl aminophenoxy) -alkanes (Ⅰ) are highly effective against all three schistosomiasis infections in experimental animals, but these compounds are more toxic than Large, especially serious damage to the optic nerve.We changed its chemical structure, synthesis of α, ω-bis (p-alkoxyphenylamino) -alkanes (Ⅱ) and N, N’- Phenyl) -diacetylamine (Ⅲ) and hydrocarbon diester (Ⅳ) compounds, in order to compare the chemical structure of the relationship between efficacy and toxicity.