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目的:探讨冠心病患者超敏C反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)水平及其临床意义。方法:选择2013年8月至2015年8月博罗县罗阳镇卫生院收治的126例冠心病患者,其中稳定型心绞痛(SAP)42例为S组,不稳定心绞痛(UAP)38例为U组,急性心肌梗死(AMI)46例为A组,另随机选取同期健康自愿者40例为对照组,分别对各组人员hs-CRP和cTnI,2种指标进行检测,记录并分析3组冠心病患者冠状动脉狭窄程度和斑块性质,并统计分析不同冠状动脉狭窄程度和斑块性质的hs-CRP和cTnI水平。结果:3组患者hs-CRP和cTnI水平均明显高于对照组(P<0.05),A组两种水平与S组和U组相比均明显升高(P<0.05),且U组两种水平均高于S组(P<0.05);U组和A组冠状动脉狭窄程度以轻度和中度为主(P<0.05),而S组冠状动脉狭窄程度主要是重度(P<0.05);3组患者hs-CRP与冠状动脉狭窄程度有关(P<0.05)),3组中有软斑块的患者hs-CRP水平明显高于有硬斑块的(P<0.05)。结论:hs-CRP升高是反应冠心病患者炎症反应和组织损伤的指标,而cTnI增高则表明冠心病患者心肌缺血损伤,联合检测hs-CRP和cTnI的水平对不同类型冠心病患者在临床诊断上有较高的预测价值。
Objective: To investigate the levels of hs-CRP and cTnI in patients with coronary heart disease and their clinical significance. Methods: A total of 126 patients with coronary heart disease were admitted to Luo Yang Hospital, Boluo County from August 2013 to August 2015. Among them, 42 patients with stable angina pectoris (SAP) were in group S and 38 patients with unstable angina pectoris (UAP) 46 cases of acute myocardial infarction (AMI) were in group A, and another 40 cases of healthy volunteers were randomly selected as control group. Two indexes of hs-CRP and cTnI were detected in each group. Three groups of crowns were recorded and analyzed The degree of coronary stenosis and plaque quality in patients with coronary heart disease, and statistical analysis of hs-CRP and cTnI levels of different degree of coronary artery stenosis and plaque properties. Results: The levels of hs-CRP and cTnI in the three groups were significantly higher than those in the control group (P <0.05). The two levels in group A were significantly higher than those in group S and U (P <0.05) (P <0.05). The severity of coronary artery stenosis in group U and group A was mild and moderate (P <0.05), but the degree of coronary stenosis in group S was mainly severe (P <0.05) ). The hs-CRP level was significantly correlated with the degree of coronary artery stenosis in the three groups (P <0.05). The level of hs-CRP was significantly higher in the three groups with soft plaque than in the hard plaque (P <0.05). CONCLUSIONS: Increased hs-CRP is an indicator of inflammatory reaction and tissue damage in patients with coronary heart disease. Increased cTnI indicates that myocardial ischemia injury in patients with coronary heart disease, combined detection of hs-CRP and cTnI levels in different types of patients with coronary heart disease in clinical Diagnosis has a higher predictive value.