近十年,国外有不少关于药物设计的综述和专著,本文是Ariens从生化代谢即药效和药物动力学角度所写的同类综述最新的一篇,但不涉及定量的结构-活性关系和Hansch最佳取代基方法。药物设计的后一种方法可参见本刊所载综述。至于量子化学与生物活性分子的设计方面的综述文,本刊将在以后再刊载。 In the last decade, there are many reviews and monographs on drug design in foreign countries. This article is the latest one from a review of biochemical metabolism, namely pharmacodynamics and pharmacokinetics, but does not involve quantitative structure-activity relationships and Hansch best substituent method. The latter method of drug design can be found in this publication. As for the review of the design of quantum chemistry and bioactive molecules, this issue will be reproduced later.