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测定有机硅烷化、聚丙烯酰胺和聚苯乙烯３ 种包埋体磁性氧化铁在水中溶解度分别为＜ ０ ．１ ％ 、５ ．６ ％ ±０ ．４ ％ 和３ ．９ ％ ±０ ．５ ％ ；模拟胃酸条件下浸泡２４ｈ 的溶解度分别为１３ ．４ ％ ±０ ．４ ％ ，１２ ．４ ％ ±０ ．８ ％ 和１０ ．５ ％ ±０ ．２ ％ ；用０ ．０１ ～１０ｍｍｏｌ／ Ｌ不同浓度的有机硅烷化磁性氧化铁溶液在磁共振仪上测定不同铁浓度下 Ｔ２信号强度显示， Ｔ２ 信号强度随铁浓度增加而下降；小鼠口服溶液后１ｈ 和４ｈ ，铁主要集中于胃和肠；家兔和小鼠喂药后分别饲养４ 周和２ 周，活动如常，未见不良反应。结果表明，有机硅烷化氧化铁颗粒有可能用作口服磁共振造影剂。
Determination of organic silanization, polyacrylamide and polystyrene embedding three kinds of magnetic iron oxide solubility in water were <0. 1%, 5. 6% ± 0. 4% and 3. 9% ± 0. 5%; simulated gastric acid soak 24h solubility were 13. 4% ± 0. 4%, 12. 4% ± 0. 8% and 10. 5% ± 0. 2%; with 0. 0.01 ~ 10mmol / L different concentrations of organosilanized magnetic iron oxide solution measured by magnetic resonance spectroscopy T2 signal intensity under different iron concentrations showed that T2 signal intensity decreased with increasing iron concentration; oral solution 1h and 4h after the mice iron Mainly concentrated in the stomach and intestine; rabbits and mice were fed for 4 weeks and 2 weeks, activity as usual, no adverse reactions. The results show that organosilanized iron oxide particles are likely to be used as oral MR contrast agents.