目前认为克罗恩病(CD)是遗传易感者受环境因素作用而发病,其发病符合多基因病的遗传规律,其遗传易感性主要表现在家族聚集现象及双胞胎共患率上。近年来,随着人类基因组计划的进展和多基因病研究及统计学方法的发展,已发现了人类CD的第一个易感基因—NOD_2基因,现命名为CARD15基因,本文就NOD_2基因及其与CD易感性的研究进展作一综述。 Currently, Crohn’s disease (CD) is a susceptible genetic predisposition to environmental factors and the incidence of the disease is consistent with the genetic rule of polygenic disease, the genetic predisposition mainly in the phenomenon of familial aggregation and twin comorbidity. In recent years, along with the progress of human genome project and the development of polygenetic diseases and statistical methods, the first novel gene of human CD, NOD_2 gene, has been found and named CARD15 gene. In this paper, NOD_2 gene and its And CD susceptibility of the research progress is reviewed.