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目的 探讨IgG、C3 在莱姆病皮肤慢性游走性红斑病变中的分布和表达。方法 应用微波免疫组化S P法检测了 9例莱姆病和临床疑诊为莱姆病患者的皮肤慢性游走性红斑病变组织 ,观察病变组织中IgG和C3 的表达并与正常人皮肤组织对照。结果 研究发现IgG和C3 阳性表达的强度以及分布范围在病变组织角质层和颗粒层较显著。 4例莱姆病患者血清学检查、病变组织硝酸银染色、IgG、C3 免疫组化染色结果均呈阳性。结论 IgG、C3 在莱姆病皮肤慢性游走性红班病变中的表达与慢性游走性红班的形成相关
Objective To investigate the distribution and expression of IgG and C3 in chronic migratory erythema of Lyme disease. Methods Nineteen patients with lyme disease and clinically suspected Lyme disease were examined by microwave immunohistochemical SP method. The expression of IgG and C3 in diseased tissues was observed and compared with that of normal human skin . Results The results showed that the intensity and distribution of IgG and C3 positive expression in the stratum corneum and granular layer of the lesion were more significant. 4 cases of Lyme disease patients serological examination, lesions of silver nitrate staining, IgG, C3 immunohistochemical staining results were positive. Conclusions The expression of IgG and C3 in chronic migratory red band in Lyme disease is related to the formation of chronic migratory red band