骨巨细胞瘤是原发性骨肿瘤之一。自1818年Corper首次报告以来,直到1940年Jaffe才确定了病理诊断和分级标准。近年来文献报告日益增多,目前虽然采用了电镜、组织培养、免疫组化等方法进行深入的研究,但该肿瘤的组织来源仍无定论。本文通过对18例病理确诊的骨巨细胞瘤,根据其病理形态和临床资料,结合文献进行分析探讨。临床资料本组18例中男性10例,女性8例。最小19岁,最大50岁。发生于胫骨下段6例、胫骨上段4例、股骨下段4例、肱骨上段2例、胸椎1例、腓骨小头1例。肿物渐增大,局部肿痛,部分有骨性隆起,2例触诊有乒乓球感,X线示骨质破坏产生溶骨现象3例,有典型泡沫样囊状阴影4例,肿 Giant cell tumor of bone is one of the primary bone tumors. Since the first report of Corper in 1818, it was not until 1940 that Jaffe established pathological diagnosis and grading criteria. In recent years, there have been more and more reports in the literature. Although electron microscopy, tissue culture, and immunohistochemistry are used for in-depth studies at present, the origin of the tumor is still inconclusive. This article through 18 cases of pathologically diagnosed giant cell tumor of bone, according to its pathological morphology and clinical data, combined with literature analysis. Clinical data in this group of 18 cases of 10 males and 8 females. The youngest is 19 years old and the oldest is 50 years old. Occurred in 6 cases of the lower humerus, 4 cases of the upper part of the humerus, 4 cases of the lower femur, 2 cases of the upper humerus, 1 case of thoracic spine, 1 case of small head of the sacrum. Tumors gradually increased, local swelling and pain, some bone bulges, 2 cases of palpation of table tennis, X-ray shows that the destruction of bone caused osteolytic phenomenon in 3 cases, there are 4 cases of typical foam-like cystic shadow, swollen