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目的 探讨雌激素对绝经后脑梗死患者神经功能缺损及智能障碍的改善作用。方法 采用改良爱丁堡 斯堪的那维亚卒中量表 (MESSS)和Folstein简易智能状态检查法 (MMSE) ,对一组绝经后脑梗死患者在雌激素治疗前后进行了测试。结果 妊马雌酮 (ERT)组与常规治疗组相比 ,ERT组MESSS评分减低(P <0 .0 1) ,MMSE成绩提高 (P <0 .0 1)。结论 雌激素替代疗法能促进神经功能康复 ,也可改善智能障碍。
Objective To investigate the effect of estrogen on the neurological deficits and mental retardation in postmenopausal patients with cerebral infarction. Methods A group of postmenopausal patients with cerebral infarction was tested before and after estrogen therapy using the modified Scandinavia Stroke Scale (MESSS) and the Folstein Simple State of Mind (MMSE). Results Compared with the conventional treatment group, the MESSS score of ERT group was decreased (P <0.01) and MMSE score was increased (P <0.01). Conclusion Estrogen replacement therapy can promote neurological rehabilitation, but also improve mental retardation.