邻苯二甲酸酯类化合物(phthalic acid esters,PAEs)作为工业用增塑剂,广泛应用于各种生产、生活用品。其特点是产量大、用途广、毒性隐匿,现已成为一类最为普遍的威胁人类健康的环境污染物。作为内分泌干扰物,PAEs可以通过多种途径进入人体并蓄积,干扰机体内分泌,对女性生殖健康产生重要的影响。研究发现,PAEs可能是通过过氧化物酶体增殖物激活型受体γ(PPARγ)影响胎盘的形成及滋养细胞的侵蚀性,从而导致了自然流产的发生。 Phthalates esters (PAEs) as industrial plasticizers, are widely used in various production and daily necessities. It is characterized by its large yield, wide range of uses and its potential for occult toxicity, and has now become one of the most common types of environmental pollutants that threaten human health. As an endocrine disruptor, PAEs can enter the body through a variety of ways and accumulate, interfere with the body’s endocrine, have a significant impact on female reproductive health. The study found that PAEs may be through the peroxisome proliferator-activated receptor γ (PPARγ) affect the formation of placenta and trophoblast cell erosion, resulting in the occurrence of spontaneous abortion.