越来越多的证据表明,空气污染与心血管疾病发病率和死亡率有关,尤以空气颗粒物(particulate matter,PM)的影响最为人们所关注,其致病机制亦有较多研究报道。本文将从流行病学研究、动物毒理实验及体外细胞实验综合阐述空气颗粒物暴露对心血管损害的生物学机制,包括炎症损伤、氧化应激和对凝血系统、自主神经系统及内皮功能的影响等。 More and more evidences show that air pollution is related to the morbidity and mortality of cardiovascular diseases, especially the most affected by particulate matter (PM). More studies have reported on its pathogenesis. In this paper, the biological mechanisms of airborne particulate exposure to cardiovascular damage, including inflammatory injury, oxidative stress, and effects on the coagulation system, autonomic nervous system and endothelial function, will be elaborated from epidemiological studies, animal toxicological experiments and in vitro cell experiments Wait.