最近的临床研究证实慢性心衰患者有外周阻力动脉内皮功能不全,以及流速依赖性内皮介导的动脉管扩张(FDD)能力受损。有证据表明,慢性心衰时自由基形成增加,这说明慢性心衰患者血管内皮功能不全,至少部分地是因氧自由基致NO失活程度增加所致。最近已证实抗氧化剂维生素C可防止NO Recent clinical studies have demonstrated peripheral resistance to endothelial dysfunction in patients with chronic heart failure and impaired ability to flow-dependent endothelial-mediated arterial dilatation (FDD). Evidence suggests that there is an increase in free radical formation in chronic heart failure, suggesting that vascular endothelial dysfunction in patients with chronic heart failure is due, at least in part, to increased levels of NO inactivation by oxygen free radicals. Antioxidant vitamin C has recently been shown to prevent NO