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细胞内抗体(intracellular antibody,intrabody)又称内抗体,是一种能够在细胞内表达,并通过定位序列定位于胞内亚细胞结构(如胞浆、胞核、内质网和线粒体等),与靶抗原结合并发挥其生物活性的一类抗体。胞内抗体技术主要应用在抑制病毒复制特别是HIV-1复制、肿瘤基因治疗方面,已经逐渐拓展到中枢神经系统疾病、移植排斥和自身免疫性疾
Intrabody antibody, also known as an internal antibody, is an antibody that can be expressed intracellularly and localized to intracellular subcellular structures (such as cytoplasm, nucleus, endoplasmic reticulum and mitochondria, etc.) through localization sequences, A class of antibodies that bind to a target antigen and exert their biological activity. Intracellular antibody technology is mainly used in inhibiting viral replication, especially HIV-1 replication, cancer gene therapy, has gradually expanded to the central nervous system diseases, transplant rejection and autoimmune diseases