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免疫毒素是一类有潜在用途的新制剂,它将有助于科学家和临床医生解决移植和癌症治疗上的难题。免疫毒素这个名称系指一种抗原或抗体与毒素共价交联而成的杂交分子,它可以特异性地杀死带有相应抗原或抗体的靶细胞亚群。本文讨论免疫毒素研究的最新进展及其在移植生物学和肿瘤学等各种实验模型中的应用。
Immunotoxins are a new class of potentially useful preparations that will help scientists and clinicians solve the problems of transplantation and cancer treatment. The term immunotoxin refers to a hybrid molecule of antigen or antibody covalently crosslinked with a toxin that specifically targets a subpopulation of target cells with the corresponding antigen or antibody. This article discusses the recent advances in immunotoxin research and its application in a variety of experimental models such as transplantation biology and oncology.