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目的探讨检测肺癌患者手术前后外周血CD4+CD25+调节性T细胞的临床意义。方法原发性肺癌患者43例(肺癌组),健康体检者20例(健康对照组)。应用流式细胞术检测其外周血CD4+CD25+调节性T细胞的水平。结果肺癌组患者手术前外周血CD4+CD25+调节性T细胞表达高于健康对照组(P<0.01);肺癌组患者术后30d时外周血CD4+CD25+调节性T细胞水平较术前明显下降(P<0.05)。结论肺癌患者外周血CD4+CD25+调节性T细胞的水平增高;肺癌患者术后外周血CD4+CD25+调节性T细胞的水平下调,提示术后机体抗肿瘤免疫功能有了一定程度恢复。
Objective To investigate the clinical significance of detecting CD4 + CD25 + regulatory T cells in peripheral blood of patients with lung cancer before and after operation. Methods 43 patients with primary lung cancer (lung cancer group), 20 healthy subjects (healthy control group). The level of CD4 + CD25 + regulatory T cells in peripheral blood was detected by flow cytometry. Results The expression of CD4 + CD25 + regulatory T cells in peripheral blood of patients with lung cancer before surgery was significantly higher than that of healthy controls (P <0.01). The levels of CD4 + CD25 + regulatory T cells in peripheral blood of patients with lung cancer were significantly lower than those before surgery P <0.05). Conclusions The level of CD4 + CD25 + regulatory T cells in peripheral blood of patients with lung cancer is increased. The level of CD4 + CD25 + regulatory T cells in peripheral blood of patients with lung cancer is down-regulated, suggesting that the anti-tumor immune function of the patients has been recovered to a certain extent.