论文部分内容阅读
血吸虫病是一种严重危害人类健康,影响畜牧业生产的人兽共患寄生虫病.为了解决以往血吸虫病疫苗制备的虫源困难,保证疫苗的安全性,近年来已重点发展到分子疫苗的研究.不仅找到了许多能诱导保护性免疫力的保护性抗原,而且还通过基因工程技术对许多保护性抗原进行了蛋白基因的克隆和有效表达.谷胱甘肽-S-转移酶(GST),磷酸丙糖异构酶(TPI)及副肌球蛋白已进入人体试验阶段.本文主要就GST、TPI、副肌球蛋白及 31/32kDa蛋白的基本结构、来源、生化免疫学特性、保护性免疫力及免疫机制作一概述.
Schistosomiasis is a zoonotic parasitic disease that seriously endangers human health and affects the production of animal husbandry.In order to solve the problem of insect origin in the preparation of schistosomiasis vaccine and ensure the safety of the vaccine in recent years, Research not only found many protective antigens that can induce protective immunity but also cloned and expressed many protective antigens through genetic engineering.Glutathione-S-transferase (GST) , Triosephosphate isomerase (TPI) and paramyosin have entered the human test phase.In this paper, the basic structure of GST, TPI, paramyosin and 31 / 32kDa protein, source, biochemical and immunological properties, protective Immunity and immune mechanisms to make an overview.