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历来认为恶性黑色素瘤对常规分割放疗抗拒,恶性黑色素瘤细胞体外实验生存曲线显示宽的肩峰,肯定了这种亚致死性放射损伤细胞具有很大的修复能力。越来越多的临床资料进一步提供了每次照射大于4～5Gy 可以明显提高这种肿瘤放疗效果的证据.本研究是比较以前认为对恶性黑色素瘤有效的两个高剂量分割放疗方案对肿瘤的效果以及对周围正常组织的放射损伤.
Historically, malignant melanoma has been shown to be resistant to conventional segmented radiotherapy. The survival curve of malignant melanoma cells in vitro shows a broad shoulder, confirming that this sub-lethal radiation-damaging cell has a great ability to repair. More and more clinical data further provide evidence that the effect of this radiotherapy can be significantly improved by each irradiation of more than 4 to 5 Gy. This study compares two high-dose fractionated radiotherapy regimens previously considered effective for malignant melanoma to tumors. Effects and radiation damage to surrounding normal tissues.