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研究观察了家兔在高胆固醇饲料的喂养下,可能诱发红细胞膜的脂质过氧化损伤。在喂养2个月前后的比较中,发现血浆总胆固醇(PTC)和低密度脂蛋白胆固醇(PLDL-C)显著升高;红细胞膜低密度脂蛋白胆固醇(MLDL-C)和共轭双烯(MCD)及红细胞丙二醛(RMDA)明显上升:MLDL-C由(3.4±1.9)μmol/g上升到(5.9±1.8)μmol/g;MCD(140.6±54.7)μmol/g上升到(.291.8±140.2)nmol/g;RMDA(14.3±1.9)nmol/g上升至(17.4±2.3)nmol/g,差异有非常显著性意义(P<0.01)。但红细胞超氧化物歧化酶(RSOD)和膜流动性(LFU)显著下降,RSOD由(1751.0±265.7)U/g下降到(1321.6±343.6)U/g;LFU由1.8±0.8下降到0.8±0.3(P<0.01)。结果显示,高胆固醇饲料不仅引起高胆固醇血症,而且可以诱导红细胞膜生物化学和生物物理学的一系列改变。
The study observed that rabbit fed with high cholesterol diet may induce lipid peroxidation injury of erythrocyte membrane. Plasma levels of total cholesterol (PTC) and low-density lipoprotein cholesterol (PLDL-C) were significantly elevated in the two months before feeding; the levels of erythrocyte membrane-derived low density lipoprotein cholesterol (MLDL-C) and conjugated diene MCD and RMDA increased significantly from (3.4 ± 1.9) μmol / g to (5.9 ± 1.8) μmol / g and from MCDL (140.6 ± 54.7) μmol / g to ± 140.2) nmol / g and RMDA (14.3 ± 1.9) nmol / g increased to (17.4 ± 2.3) nmol / g, respectively. The difference was statistically significant (P <0.01). (RSD) and membrane fluidity (LFU) of erythrocytes decreased significantly (RSD) from (1751.0 ± 265.7) U / g to (1321.6 ± 343.6) U / g; LFU decreased from 1.8 ± 0.8 to 0.8 ± 0.8 0.3 (P <0.01). The results showed that high cholesterol feed not only cause hypercholesterolemia, but also induce a series of changes in red blood cell membrane biochemistry and biophysics.