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研究观察了家兔在高胆固醇饲料的喂养下，可能诱发红细胞膜的脂质过氧化损伤。在喂养2个月前后的比较中，发现血浆总胆固醇（PTC）和低密度脂蛋白胆固醇（PLDL-C）显著升高;红细胞膜低密度脂蛋白胆固醇（MLDL-C）和共轭双烯（MCD）及红细胞丙二醛（RMDA）明显上升:MLDL-C由（3.4±1.9）μmol／g上升到（5.9±1.8）μmol／g;MCD（140.6±54.7）μmol／g上升到（.291.8±140.2）nmol／g;RMDA（14.3±1.9）nmol／g上升至（17.4±2.3）nmol／g，差异有非常显著性意义（P＜0.01）。但红细胞超氧化物歧化酶（RSOD）和膜流动性（LFU）显著下降，RSOD由（1751.0±265.7）U／g下降到（1321.6±343.6）U／g;LFU由1.8±0.8下降到0.8±0.3（P＜0.01）。结果显示，高胆固醇饲料不仅引起高胆固醇血症，而且可以诱导红细胞膜生物化学和生物物理学的一系列改变。
The study observed that rabbit fed with high cholesterol diet may induce lipid peroxidation injury of erythrocyte membrane. Plasma levels of total cholesterol (PTC) and low-density lipoprotein cholesterol (PLDL-C) were significantly elevated in the two months before feeding; the levels of erythrocyte membrane-derived low density lipoprotein cholesterol (MLDL-C) and conjugated diene MCD and RMDA increased significantly from (3.4 ± 1.9) μmol / g to (5.9 ± 1.8) μmol / g and from MCDL (140.6 ± 54.7) μmol / g to ± 140.2) nmol / g and RMDA (14.3 ± 1.9) nmol / g increased to (17.4 ± 2.3) nmol / g, respectively. The difference was statistically significant (P <0.01). (RSD) and membrane fluidity (LFU) of erythrocytes decreased significantly (RSD) from (1751.0 ± 265.7) U / g to (1321.6 ± 343.6) U / g; LFU decreased from 1.8 ± 0.8 to 0.8 ± 0.8 0.3 (P <0.01). The results showed that high cholesterol feed not only cause hypercholesterolemia, but also induce a series of changes in red blood cell membrane biochemistry and biophysics.