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[目的]探讨胃间质瘤(GST)临床病理特点、手术治疗及预后。[方法]回顾性分析1997～2007年间37例手术切除的GST临床病理资料。[结果]37例GST中肿瘤位于胃底部、胃体部、胃窦部分别为6例、11例、20例,肿瘤平均直径5.45±4.53cm。免疫组化分析CD117阳性表达率为97.0%。全组35例施行肿瘤完全切除术,另2例分别行姑息切除或活检。32例患者获随访,1、3、5年生存率分别为97.0%、88.2%、81.1%。Fletcher恶性风险分级与生存率密切相关(P=0.002),极低度、低度、中度风险组与高度风险组间生存率差异有显著性意义(P值均<0.05)。[结论]应高度重视GST初次手术的完全切除,对恶性风险较高的GST需积极施行切除范围较大的手术治疗。
[Objective] To investigate the clinicopathological features, surgical treatment and prognosis of gastric stromal tumors (GST). [Methods] A retrospective analysis of 37 cases of surgical resection of GST from 1997 to 2007 clinical and pathological data. [Results] Tumors were located in the bottom of the stomach in 37 cases of GST. The gastric body and gastric antrum were 6 cases, 11 cases and 20 cases, respectively. The mean tumor diameter was 5.45 ± 4.53 cm. Immunohistochemical analysis of CD117 positive rate was 97.0%. The whole group of 35 cases performed complete tumor resection, the other two cases were treated with palliative resection or biopsy. Thirty-two patients were followed up. The 1, 3, 5-year survival rates were 97.0%, 88.2% and 81.1% respectively. Fletcher’s malignancy classification was closely related to the survival rate (P = 0.002). There was significant difference in the survival rates between the low-risk group, the moderate-risk group and the high-risk group (all P <0.05). [Conclusions] It is necessary to attach great importance to the complete resection of the primary GST, and actively perform the surgical resection for the GST with high malignant risk.