含氟的有机化合物是近代有机化学中一个较为新颖的领域。除了因为氟的有机化合物具有特殊的物理和化学性质以外,它的生理活性也饶有兴趣。最早受人注意的是氟乙酸类化合物,这类化合物具有强烈的生理毒性,而被用作杀虫(鼠)药。在多种药物中,氟代衍生物也颇引人注意。二次大战期间,合成了各种喹啉、吖啶类的氟化物作为抗疟药。虽然由于它们的毒性没有应用,但是他们的生理作用是肯定的。此外,在含氟的局部麻醉,磺胺,砜类等类型中,也分别显示出它们的生理作用。氨基酸的氟化物具有多种效用,氟代苯丙氨酸对某些细菌、芽胞的抑制作用大于磺胺噻唑,氟代苯丝氨酸也具有相当的抗菌作用。最近,在可的松类化合物中也出现了氟代可的松。由于氟的生理活泼性,引起了许多肿瘤药物工作者的注意,将氟引到有关的化学结构中,也有可能产生 Fluorine-containing organic compounds is a relatively new field in modern organic chemistry. Apart from the special physical and chemical properties of fluorine-containing organic compounds, its physiological activity is also of interest. The earliest attention was that fluoroacetic compounds, these compounds have a strong physiological toxicity, and was used as insecticide (rat) medicine. Among many drugs, fluoro derivatives are also attractive. During the Second World War, a variety of quinoline and acridine fluoride compounds were synthesized as antimalarial drugs. Although their application is not as toxic as they are, their physiological role is affirmative. In addition, fluorinated topical anesthetics, sulfonamides, sulfones and the like, also show their physiological effects. Amino acid fluoride has a variety of utility, fluorinated phenylalanine inhibition of certain bacteria, spores greater than sulfathiazole, fluorinated benzene serine also has considerable antibacterial effect. Recently, cortisone also appeared in cortisone compounds. Due to the physiological activity of fluorine, many cancer drug workers have drawn the attention that the introduction of fluorine into the chemical structure may also occur