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硝酸甘油—加压素 硝酸甘油是强效静脉扩张剂,对动脉也有轻微扩张作用,在输注加压素时给予硝酸甘油可以抵消加压素对心脏的毒性作用。同时它可以降低由加压素诱导的高门静脉阻力,从而增强加压素使门脉压减低的效果。从硝酸甘油和加压素联合应用的两细临床对比试验结果来看,是令人鼓舞的。若能证实,这种联合用药可以成为治疗严重静脉曲张出血的首选疗法。在加压素—硝酸甘油的研究中,亚硝酸甘油由静脉给药或舌下给予,其剂量要调整好使收缩压维持在90mmHg以上,由于硝酸甘油从皮肤吸收不可靠,故经皮肤给药方法已有疑问。
Nitroglycerin - Vasopressin Nitroglycerin is a potent venous dilator that also has a slight dilation effect on the arteries. Administration of nitroglycerin during the infusion of vasopressin counteracts the toxic effects of vasopressin on the heart. At the same time it can reduce vasopressin-induced high portal vein resistance, thereby enhancing vasopressin portal pressure to reduce the effect. The combination of nitroglycerin and vasopressin in two small clinical comparison test results is encouraging. If confirmed, this combination can be the treatment of choice for the treatment of severe varicose bleeding. In the study of vasopressin-nitroglycerin, nitrous acid glycerin is administered intravenously or sublingually in an amount adjusted to maintain the systolic blood pressure above 90 mmHg. Since nitroglycerin is not reliably absorbed from the skin, transdermal administration Method has been in doubt.