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目的优化离子凝聚法制备阿魏酸壳聚糖微球的工艺,并研究其缓释机制。方法运用Doehlert设计、多重相应的渴求函数优化法对阿魏酸壳聚糖微球的工艺进行优化。通过显微镜观察和差示热分析研究微球结构和药物状态,探讨释药机制。结果投药量和交联液pH值对包封率有很大影响。在优化条件下,阿魏酸壳聚糖微球的平均包封率为73.77%,平均载药量为8.08%,药物释放符合Higuchi方程和Weibull分布。药物以微晶状态分布于微球的骨架结构中,未与壳聚糖发生作用。结论离子凝聚法制备的壳聚糖微球的缓释行为与其网状骨架结构相关。
OBJECTIVE To optimize the technology of preparing ferulic acid chitosan microspheres by ion agglomeration and to study its mechanism of sustained release. Methods The Doehlert design was used to optimize the process of ferulic acid chitosan microspheres by multiple corresponding thirst function optimization methods. The microstructure and drug status of the microspheres were investigated by microscopy and differential thermal analysis, and the mechanism of drug release was discussed. Results The dosage and the pH value of the crosslinking solution have a great influence on the entrapment efficiency. Under optimal conditions, the average entrapment efficiency of ferulic acid chitosan microspheres was 73.77% and the average drug loading was 8.08%. The drug release was in accordance with Higuchi equation and Weibull distribution. Drugs in the microcrystalline state distribution in the microstructure of the microsphere, did not interact with chitosan. Conclusion The sustained release behavior of chitosan microspheres prepared by ionic coagulation is related to its network structure.