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1987—1992年间,以抗凝血剂(代号P)为基底药物,从配伍增效角度作了44种药剂的筛选,得到编号为88—1、88—9的两种复方灭鼠剂。经测定,88—1、88—9对小白鼠致死中量在16mg/kg左右,比敌鼠钠强3—4倍,试鼠死二高峰在48小时左右;对家禽家畜更安全;热稳定性良好,在52±2℃温箱内贮存2周毒刀不减,维生素K_l是其解毒剂;88—1、88—9对南方各种主要家鼠和农田害鼠灭效较好,经湖南、安徽、云南各地应用,群众性大面积防治,平均灭鼠率达90％以上。
From 1987 to 1992, 44 kinds of pharmaceuticals were screened from the perspective of compatibility and synergy with anticoagulant (code P) as the base drug, and two compound rodenticides numbered 88-1 and 88-9 were obtained. It has been determined that the lethal dose of 88-1,88-9 to mice is about 16mg / kg, which is 3-4 times stronger than that of natriuretic and the peak level of death of test rats is about 48 hours; safer to poultry and livestock; Sexual good, in the 52 ± 2 ℃ incubator storage for 2 weeks unabated, vitamin K_l is its antidote; 88-1,88-9 on the south of various major domestic mice and farm pests played a better off by Hunan, Anhui, Yunnan around the application of large-scale mass control, the average rate of rodent control more than 90%.