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近12年来,挪威发生的大多数流行性脑脊髓膜炎病例均由对氨苯磺胺耐药的脑膜炎球菌所致。B vre 等发现有88%的菌株,对磺胺嘧啶的最小抑菌浓度>100mg/L。而在带菌者中,对氨苯磺胺耐药的菌株比较少。据1975年的一次调查,在健康带菌者中仅22.6%的菌株呈现耐药性。当前挪威的流行菌株主要为15和16型。作者为了观察不同流行期间流脑菌型、耐药性和毒力标志间的关系,分别收集2个时期的病人和带菌者菌株,并进行了分析比较。其中180株流脑病人菌株分别从1975和1976年的患者中获得,另69株为1981年12月至1982年5月间获得。
For the past 12 years, most cases of meningococcal meningitis in Norway have been caused by meningococcal-resistant meningococci. B vre and other found that 88% of the strains, the minimum inhibitory concentration of sulfadiazine> 100mg / L. Among the carriers, there were fewer strains resistant to sulfanilamide. According to a 1975 survey, only 22.6% of healthy carriers showed resistance. The prevailing strains in Norway are predominantly types 15 and 16. In order to observe the relationship between meningococcal type, drug resistance and virulence markers in different epidemic periods, the two strains of patients and carriers were collected and analyzed. Among them, 180 strains of meningitis patients were obtained from patients in 1975 and 1976, respectively, and the other 69 strains were obtained from December 1981 to May 1982.