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目的:评价氟西汀在治疗伴抑郁茎突综合征(Styloid process syndrome,SS)茎突切除术后的作用。方法:收集SS患者72例,术前术后对所有患者行抑郁自评量表(Self-rating depression scale,SDS)评定,自评标准分(T)≥50者被认为伴有抑郁症状。对伴有抑郁症状患者按单盲原则随机分为A、B两组,无伴抑郁症状的患者为C组。A组手术切除茎突后,给予连续3周口服氟西汀,剂量为20mg/d。B组手术切除茎突后给予连续3周口服安慰剂。C组单纯手术切除茎突。结果:SS患者伴抑郁症状发生率为72.22%(52/72),随访7～26个月,A组(28例)有效率(痊愈+好转)92.86%(26/28),明显高于B组(24例)83.33%(20/24)。C组(20例)有效率90%(18/20),与A组相近。所有患者均获得满意的外观,无药物不良反应。结论:SS伴抑郁症状发生率较高。SS患者术前SDS自评量表检查是必要的。对其中伴有抑郁症状的患者手术治疗后辅以抗抑郁剂氟西汀治疗疗效显著。
Objective: To evaluate the effect of fluoxetine in the treatment of styloid process syndrome (SS) after resection of the styloid process. Methods: Seventy-two patients with SS were collected. Self-rating depression scale (SDS) was assessed in all patients before operation. The self-rated score (T) ≥50 was considered to be associated with depressive symptoms. Patients with depressive symptoms according to the principle of single-blind were randomly divided into A, B two groups, without depressive symptoms in patients with C group. A group of surgical resection of the styloid process, given three consecutive oral fluoxetine dose of 20mg / d. B group after surgical resection of the styloid process given 3 consecutive weeks of oral placebo. Group C simple surgical removal of the styloid process. Results: The incidence of depressive symptoms in patients with SS was 72.22% (52/72). The follow-up period of 7 to 26 months was 92.86% (26/28) in group A (28 cases), which was significantly higher than that in group B Group (24 cases) 83.33% (20/24). Group C (20 cases) was 90% (18/20), similar to group A. All patients achieved a satisfactory appearance, no adverse drug reactions. Conclusion: The incidence of depression with SS is higher. SS patients preoperative SDS self-assessment scale examination is necessary. Among them, patients with depressive symptoms were treated with anti-depressant fluoxetine after surgery.