在DNA正常代谢中,碱基错配、插入、缺失或重排都可导致基因重组DNA复制错误。如果DNA复制前这些错误不能矫正,造成的突变就固定在基因组内,这些突变是导致人类许多疾病(包括肿瘤)的重要原因。目前认为对DNA损伤的修复,主要存在两种机制,一种是切割修复,主要对各种因素造成的DNA In the normal metabolism of DNA, base mismatches, insertions, deletions, or rearrangements can all lead to errors in gene recombination DNA replication. If these errors before DNA replication cannot be corrected, the resulting mutations are fixed in the genome, and these mutations are an important cause of many human diseases including tumors. At present, there are two main mechanisms for the repair of DNA damage, one is cleavage repair, and the DNA is mainly caused by various factors.