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目的 了解广州市孕妇孕中、晚期硒碘营养状况。方法 用砷铈接触法测定尿碘 ,用放射免疫分析法(RIA)测定血清甲状腺素 (T4)、促甲状腺激素 (TSH) ,荧光光度法测定静脉全血硒。结果 孕中期血硒含量 (0 1375± 0 0 96 9) μg/ml及孕晚期血硒含量 (0 15 2 8± 0 0 85 9) μg/ml,远低于我国中硒区成人血硒值 (0 35± 0 0 2 ) μg/ml。孕中、晚期血硒含量无明显变化 (P >0 0 5 )。孕中期尿碘中位数为 2 4 9 3μg/L ,<10 0 μg/L者占 4 5 % ;孕晚期尿碘中位数为 2 4 1 2 μg/L ,<10 0 μg/L者占 12 5 % ,两期尿碘值自身比较差异无统计学意义 (P >0 0 5 )。孕中期血清T 4(15 7 0± 6 6 4 )nmol/L ,在正常范围者占 5 8 2 % ;孕晚期血清T4(12 4 4± 5 9 4 )nmol/L ,在正常范围者占 78 3%。孕中期血清TSH(中位数 3 9mU/L) >5mU/L者占 34 3% ,孕晚期血清TSH (中位数 6 9mU/L) >5mU/L者占81 8%。中晚期自身比较TSH >5mU/L与 >5mU/L的人数构成差异有统计学意义 (P <0 0 1)。结论 广州市孕妇硒碘营养状况良好 ,孕晚期血清TSH >5mU/L者 (81 8% )较多 ,与尿碘、T4水平不一致 ,有待进一步研究。
Objective To understand the pregnant pregnant women in Guangzhou, late selenium iodine nutrition status. Urinary iodine was measured by arsenic - cerium contact method, serum thyroxine (T4) and thyrotropin (TSH) were measured by radioimmunoassay (RIA), and whole venous selenium was measured by fluorescence spectrophotometry. Results The selenium content (0 1375 ± 0 0 96 9) μg / ml in the second trimester and the selenium in the third trimester (0 15 2 8 ± 0 0 85 9) μg / ml were much lower than those in selenium in China (0 35 ± 0 0 2) μg / ml. Selenium in late pregnancy, serum selenium content had no significant change (P> 0 05). Median urinary iodine in the second trimester was 2 493 μg / L, while in the second trimester, median urinary iodine was 24 1 2 μg / L and <10 0 μg / L respectively Accounting for 12 5%. There was no significant difference in urine iodine value between the two groups (P> 0.05). T 4 (15 7 0 ± 6 6 4) nmol / L in the second trimester of pregnancy was 58.2% in the normal range and T4 (12 4 4 ± 5 9 4) nmol / L in the third trimester was in the normal range 78 3%. The second trimester serum TSH (median 39mU / L)> 5mU / L was 34.3%, third trimester serum TSH (median 69mU / L)> 5mU / L was 81.8%. There was a statistically significant difference in the number of individuals with TSH> 5mU / L and> 5mU / L in the intermediate and advanced stages (P <0.01). Conclusion The selenium iodine nutrition status of pregnant women in Guangzhou is good. Serum TSH> 5mU / L in the third trimester is more (81.8%), which is inconsistent with the urinary iodine and T4 levels and needs further study.