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目的研究干扰素和丙种球蛋白治疗重症手足口症(病)的临床效果。方法抽选2014年5月至2015年2月就诊于佛山市南海区第二人民医院的手足口症患儿90例,随机分为对照组45例和观察组45例,两组患儿均接受常规治疗和护理,采用干扰素α-1b 20μg+氯化钠注射液2 ml雾化治疗,2次/d;观察组在以上治疗基础上加用丙种球蛋白1 g/(kg·d),2次/d,连续治疗2 d,比较两组患儿的临床治疗效果。结果观察组皮疹消退时间为(2.1±1.6)d,体温恢复时间为(1.32±0.70)d,神经系统症状改善时间为(1.41±0.54)d,显著低于对照组的(4.2±2.3)、(1.97±0.82)、(1.78±0.72)d,差异有统计学意义(P<0.05)。观察组显效25例,有效17例,无效3例,总有效率为93.4%;对照组显效16例,有效18例,无效11例,总有效率为75.6%,两组比较差异有统计学意义(P<0.05)。结论干扰素和丙种球蛋白联合治疗重症手足口症疗效好,值得推广。
Objective To study the clinical effects of interferon and gamma globulin in the treatment of severe hand-foot-mouth disease. Methods 90 children with HFMD who visited the Second People’s Hospital of Nanhai District in Foshan from May 2014 to February 2015 were randomly divided into control group (45 cases) and observation group (45 cases), both groups received The patients in the observation group were treated with gg (1 g / (kg · d), 2 g / (kg · d)) for 2 weeks. The patients in the observation group were treated with interferon α-1b 20μg and sodium chloride injection 2ml. Times / d, continuous treatment 2 d, the clinical efficacy of the two groups were compared. Results The skin rash subsided in the observation group was (2.1 ± 1.6) days, the body temperature recovery time was (1.32 ± 0.70) days, the neurological symptom improvement time was (1.41 ± 0.54) days, significantly lower than that in the control group (4.2 ± 2.3) (1.97 ± 0.82), (1.78 ± 0.72) d respectively, the difference was statistically significant (P <0.05). In the observation group, 25 cases were markedly effective, 17 cases were effective, 3 cases were ineffective, and the total effective rate was 93.4%. In the control group, 16 cases were markedly effective, 18 cases were effective and 11 cases were ineffective with a total effective rate of 75.6%. There was significant difference between the two groups (P <0.05). Conclusion Interferon and gammaglobulin in the treatment of severe hand-foot-mouth disease is effective and worth promoting.