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现有针对病毒靶点药物的广泛使用加速了耐药株的出现,促进了对抗流感药物宿主靶点的研究与探索。流感病毒复制需要宿主细胞因子和细胞信号通路的参与,因此干扰病毒与细胞之间的相互作用可以抑制流感病毒的复制;同时流感病毒感染初期会引起宿主的天然免疫应答,诱导调节宿主的天然免疫机制可以防御流感感染;另外,为了抑制流感感染后期引发的过度炎症反应,需要具有抗炎作用的药物来抑制流感引起的免疫失调和组织损伤。因此,针对流感病毒宿主靶点的药物研发,为流感的防治带来新的希望。
The widespread use of existing drugs targeting viral targets has accelerated the emergence of drug-resistant strains and promoted the research and exploration of targets against influenza drug hosts. Influenza virus replication requires the participation of host cytokines and cell signaling pathways, thus interfering with virus-cell interactions can inhibit the replication of influenza virus; meanwhile, the initial influenza virus infection will cause the host’s innate immune response and induce the host’s innate immunity In addition, in order to suppress the excessive inflammatory reaction induced in the late stage of influenza infection, drugs with anti-inflammatory effect are needed to suppress influenza-induced immune disorders and tissue damage. Therefore, the development of drugs targeting the target of influenza virus brings new hope for the prevention and control of influenza.