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探讨晚期胰腺癌的介入化疗加立体适形放射治疗的临床疗效。先选择性胰腺动脉化疗,药物:CF 300 mg、5-FU 1 000~1 500 mg、DDP 60~80 mg和健择1.2~2.0 g,共4次。介入化疗后或两次介入之间行立体定向放射治疗,放疗采用4~6个适形野,总剂量为35~45 Gy,4~8 Gy/次,每周3次,21例患者CR率42.85%(9/21),PR率42.85%(9/21),SD 4.76%(1/21),PD 9.52%(2/21),总有效率(CR+PR)85.70%(18/21)。初步研究结果提示,主观指标评估,2例临床症状完全消失,17例主观症状有所改善。介入化疗结合立体放射治疗晚期胰腺癌不失为临床选用的治疗手段。
To investigate the clinical effect of interventional chemotherapy combined with stereotactic radiotherapy for advanced pancreatic cancer. First selective pancreatic artery chemotherapy, drugs: CF 300 mg, 5-FU 1 000 ~ 1 500 mg, DDP 60 ~ 80 mg and 1.2 g Gentle selection, a total of 4 times. After interventional chemotherapy or between two interventions, stereotactic radiotherapy was performed. The radiotherapy was performed on 4 ~ 6 conformal fields with the total dose of 35 ~ 45 Gy, 4 ~ 8 Gy / time and 3 times per week. The CR rate of 21 patients 42.85% (9/21), PR rate 42.85% (9/21), SD 4.76% (1/21), PD 9.52% (2/21), total effective rate (CR + PR) 85.70% ). Preliminary findings suggest that subjective assessment of indicators, 2 cases of clinical symptoms disappeared completely, 17 cases of subjective symptoms improved. Interventional chemotherapy combined with stereotactic radiotherapy for advanced pancreatic cancer is a clinical choice of treatment.