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目的通过比较恶性胸腔积液、结核性渗出性胸腔积液、类肺炎性胸腔积液患者α-烯醇化酶(ENO1)、CYFRA21-1、CA125浓度,探讨胸腔积液ENO1联合血清CYFRA21-1、CA125检测在恶性胸腔积液诊断中的价值。方法采用酶联免疫吸附实验(ELISA)检测胸腔积液ENO1浓度,化学发光法检测血清CA125浓度,磁微粒化学发光法检测血清CYFRA21-1浓度,计算ENO1联合CYFRA21-1、CA125在3组胸腔积液中的灵敏度、特异度。结果 (1)恶性胸腔积液组的ENO1浓度显著升高(P<0.001),ENO1在结核性渗出性胸腔积液与类肺炎性胸腔积液相比,差异无统计学意义(P>0.05);(2)ENO1联合血清CYFRA21-1、CA125检测在恶性胸腔积液中的灵敏度及特异度分别为94%和74%、98%和48%。结论 ENO1浓度在恶性胸腔积液中升高,ENO1联合血清CYFRA21-1、CA125检测可提高诊断恶性胸腔积液的灵敏度,提高恶性胸腔积液的诊断率。
Objective To compare the concentrations of ENO1, CYFRA21-1 and CA125 in patients with malignant pleural effusions, tuberculous exudative pleural effusions, and patients with pneumocystitis-like pleural effusions, and to investigate the relationship between pleural effusion ENO1 and serum CYFRA21-1 , CA125 in the diagnosis of malignant pleural effusion value. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect pleural effusion ENO1 concentration, chemiluminescence method to detect serum CA125 concentration, magnetic particle chemiluminescence method to detect serum concentration of CYFRA21-1, calculated ENO1 combined with CYFRA21-1, CA125 in three groups pleural product Liquid sensitivity, specificity. Results (1) The concentration of ENO1 in malignant pleural effusion group was significantly increased (P <0.001). There was no significant difference in ENO1 between tuberculous exudative pleural effusion and pneumocystogenic pleural effusion (P> 0.05 ); (2) The sensitivity and specificity of ENO1 combined with serum CYFRA21-1 and CA125 in malignant pleural effusion were 94% and 74%, 98% and 48%, respectively. Conclusion The concentration of ENO1 in malignant pleural effusion increased, ENO1 combined with serum CYFRA21-1, CA125 detection can increase the sensitivity of the diagnosis of malignant pleural effusion, and improve the diagnosis of malignant pleural effusion.