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目的:探讨脑源性神经营养因子(BDNF)与持续性非卧床腹膜透析(CAPD)患者认知功能障碍的相关性。方法:以CAPD患者为研究对象,采用中文版蒙特利尔认知评估量表(MoCA)调查其认知功能,并检测血清BDNP水平,采用相关分析法探讨CAPD患者认知功能与BDNP的相关性。结果:(1)98例CAPD患者中伴有认知功能障碍者58例,占59.18%。(2)CAPD组MoCA总分、注意力、延迟回忆和抽象评分显著低于健康对照组,差异均有统计学意义(P<0.05)。(3)CAPD伴认知功能障碍组和CAPD不伴认知功能障碍组的BDNF均显著低于健康对照组,差异有统计学意义(P<0.01);CAPD伴认知功能障碍组的BDNF显著低于CAPD不伴认知功能障碍组,差异有统计学意义(P<0.01)。(4)血清BDNF与MoCA总分、注意力、延迟回忆和抽象均显著正相关(P<0.05)。结论:CAPD患者认知功能障碍患病率较高,BDNF可能与CAPD患者认知功能障碍有关。
Objective: To explore the correlation between brain-derived neurotrophic factor (BDNF) and cognitive impairment in patients with continuous ambulatory peritoneal dialysis (CAPD). Methods: The CAPD patients were studied. Cognitive function was assessed using the Chinese version of the Montreal Cognitive Assessment Scale (MoCA). Serum BDNP levels were measured. Correlation analysis was used to explore the correlation between cognitive function and BDNP in CAPD patients. Results: (1) 58 cases of CAPD patients with cognitive dysfunction accounted for 59.18%. (2) MoCA score, attention, delayed recall and abstract score in CAPD group were significantly lower than those in healthy control group (P <0.05). (3) The BDNF of CAPD with cognitive impairment group and CAPD without cognitive impairment group were significantly lower than that of healthy control group (P <0.01); BDNF of CAPD with cognitive impairment group was significantly Lower than CAPD without cognitive impairment group, the difference was statistically significant (P <0.01). (4) Serum BDNF was significantly and positively correlated with MoCA score, attention, delayed recall and abstraction (P <0.05). Conclusion: The prevalence of cognitive impairment is high in patients with CAPD. BDNF may be related to cognitive dysfunction in CAPD patients.