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目的 探讨地塞米松 (Dex)预处理对新生儿缺氧缺血性脑病 (Hypoxic- ischemicencephalopathy,HE)新生大鼠神经及体格发育的影响。方法 4日龄 SD大鼠 85只随机分为 3组 ,分别给予生理盐水、两种剂量 Dex预处理 4天 ,然后结扎左侧颈总动脉 ,放入 37℃恒温有机玻璃缺氧房中 3h。分别于生后 1 0、1 4、2 1、2 8d取全脑标本切片作 HE染色 ,测定各组大鼠总死亡率、体重、非结扎侧皮层厚度和细胞密度。结果 Dex组大鼠脑梗塞发生率及梗塞面积、体重、非结扎侧皮层厚度和细胞密度均少于对照组。低剂量 Dex组和高剂量 Dex组死亡率均高于对照组。两个 Dex剂量组间无明显差异。结论 Dex预处理对 HIE新生大鼠具有神经保护作用 ,但可抑制体格生长和大脑皮层发育 ,可能导致精神运动发育迟滞
Objective To investigate the effects of Dex preconditioning on the neurological and physical development of newborn rats with hypoxic-ischemic encephalopathy (HE). Methods Eighty four 4-day-old SD rats were randomly divided into three groups. The rats were given normal saline. The rats were pretreated with two doses of Dex for 4 days. Then the left common carotid artery was ligated and placed in 37 ℃ thermostatic PMMA hypoxia for 3 hours. Whole brain sections were harvested for HE staining at 10, 14, 22 and 28 days after birth, respectively. The total mortality, body weight, cortical thickness and cell density were measured. Results The incidence of cerebral infarction and infarct size, weight, non-ligated side cortex thickness and cell density in Dex group were less than those in control group. The mortality of low-dose Dex group and high-dose Dex group were higher than that of the control group. There was no significant difference between the two Dex dose groups. Conclusion Dex preconditioning may have neuroprotective effects on neonatal HIE rats, but it may inhibit the growth of the body and the development of the cerebral cortex, which may lead to delayed mental motor development