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肝脏具有巨大的再生能力。动物实验及临床研究表明,将肝脏切除2/3后,肝脏可在短期内恢复到原体积,功能基本保持不变。早在60年代人们就曾推测,血液中可能存在某种物质能刺激和促进肝细胞的再生。1982年Strain等最先提出血小板中含有对肝脏具有刺激作用的生长因子。1983年Michalopoulos、Nakamura、Rusell等几乎同时在各自不同的三个实验中发现活组织中存在能刺激肝细胞DNA合成的物质。随后Golda等在暴发性肝衰患者的血液中发现同样的活性物质。但到1989年才对这一物质的分子结构有了较完整的认识,并因其对肝细胞具有强力的促有丝分裂作用而将其命名为Hepatocyte Growth Factor (HGF)中译名有肝细胞生长素、促肝细胞生长素及肝细胞再生因子等。
The liver has a huge regenerative capacity. Animal experiments and clinical studies have shown that the liver 2/3 after resection, the liver can be restored to the original volume in the short term, the basic function remained unchanged. As early as the 1960s, people had speculated that there may be some substance in the blood can stimulate and promote the regeneration of liver cells. In 1982, Strain et al first proposed that platelets contain growth factors that stimulate the liver. In 1983, Michalopoulos, Nakamura and Rusell discovered in their three different experiments that there were substances in living tissues that could stimulate DNA synthesis in liver cells. Golda et al subsequently found the same active substance in the blood of patients with fulminant hepatic failure. However, it was only in 1989 that the molecular structure of this substance had a complete understanding. Hepatocyte growth factor (HGF) was named hepatocyte growth factor because of its strong mitogenic effect on hepatocytes. Promote hepatocyte growth factor and hepatocyte regeneration factor.