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目的探讨内源性肝细胞生长因子在颅内动脉瘤发病机制中的作用。方法比较颅内动脉瘤患者颅内动脉瘤腔血液和股动脉血液样品中肝细胞生长因子(HGF)的浓度。实验小鼠诱导颅内动脉瘤并用PF-04217903或DMSO处理,测定小鼠颅内动脉瘤发生率、收缩压、蛛网膜下出血率及存活率。结果脑动脉瘤血浆样品中HGF平均浓度(776±47)pg/ml显著高于股动脉瘤样品(296±34)pg/ml(P<0.001);c-Met拮抗剂增加了颅内动脉瘤破裂的风险并降低了小鼠的生存率。结论颅内动脉瘤血浆中HGF显著升高,HGF通过c-Met信号通路减少内皮细胞中的炎症反应并保护颅内动脉瘤免于破裂。
Objective To investigate the role of endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms. Methods The levels of hepatocyte growth factor (HGF) in intracranial aneurysm and blood samples of intracranial aneurysms were compared. The experimental mice were induced intracranial aneurysms and treated with PF-04217903 or DMSO to determine the incidence of intracranial aneurysms, systolic blood pressure, subarachnoid hemorrhage and survival in mice. Results The average concentration of HGF in cerebral aneurysm samples (776 ± 47 pg / ml) was significantly higher than that in femoral artery aneurysms samples (296 ± 34 pg / ml) (P <0.001). C-Met antagonists increased intracranial aneurysms Risk of rupture and reduced survival in mice. Conclusions HGF in the plasma of intracranial aneurysms is significantly increased. HGF reduces the inflammatory reaction in endothelial cells and protects the intracranial aneurysms from rupture through the c-Met signaling pathway.