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本文报道用咯萘啶治疗恶性疟30例,其治疗剂量为2mg/kg,分别经2次或3次肌注;治疗剂量为3mg/kg,3次肌注。退热时间为26-36h,原虫转阴时间为41-57h。另用本品2mg/kg,肌注2次治疗间日疟12例,退热时间为18h,原虫转阴时间为37h。有脑型疟8例全部获得救治。有氯喹未治愈的2例患者改用本品后也能见效。本品对孕妇(2例)及婴儿(1例)均未出现不良反应。本研究证明咯萘啶抗疟效果好、副反应轻,值得在临床上继续试用。
This article reports the use of pyronaridine treatment of 30 cases of falciparum malaria, the therapeutic dose of 2mg / kg, respectively, by 2 or 3 intramuscular injection; the treatment dose of 3mg / kg, 3 times intramuscular injection. Antipyretic time is 26-36h, Protozoa negative time is 41-57h. Another use of this product 2mg / kg, intramuscular injection of 12 cases of vivax malaria, antipyretic time was 18h, protozoa negative time 37h. 8 cases of cerebral malaria were all treated. Chloroquine is not cured in 2 patients switched to this product can also be effective. The product of pregnant women (2 cases) and infants (1 case) did not appear adverse reactions. This study shows that pyronaridine antimalarial effect, side effects, it is worth in the clinical trial.