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目的 评价芪茸保元汤对临床疗效及对实验动物小鼠抗疲劳能力、免疫功能影响和急性毒性反应。方法 临床观察以中医辨证和西医血肌肝作为指征。给予芪茸保元汤 ,每日 3次 ,每次 2 5ml;实验研究选雌雄小鼠 ,将中药分为大、中、小剂量 ,分别做负重游泳、碳粒廓清、灌胃急毒试验。结果 临床病人用药后疗效满意 ;实验动物大剂量能显著提高小鼠抗疲劳能力及免疫功能 ,无急性毒性反应。结论 芪茸保元汤能有效地提高人体的免疫功能及生存能力 ,较好地稳定肾功能 ,从而延缓慢性肾功能衰竭的进程。
Objective To evaluate the clinical efficacy of Qirong Baoyuan Decoction and its effects on the anti-fatigue ability, immune function and acute toxicity of experimental animals. Methods Clinical observations were based on traditional Chinese medicine syndrome differentiation and Western medicine blood muscle liver as an indication. Give Qirong Baoyuan Decoction, 3 times a day, 25ml each time; Experimentally select male and female mice and divide the Chinese herbal medicine into large, medium and small doses, and do weight-bearing swimming, carbon particle clearance, and oral administration of acute toxicity test. Results The curative effect was satisfactory after the treatment of clinical patients; large doses of experimental animals could significantly improve the ability of mice to resist fatigue and immune function without acute toxicity. Conclusion Qirong Baoyuan Decoction can effectively improve the body’s immune function and survivability, stabilize renal function, and delay the progression of chronic renal failure.