已知,胰岛素诱发的低血糖症可引起胰岛α细胞释放胰高血糖素的反应。毒蕈碱受体阻滞剂阿托品对此反应无影响。当糖尿病人合并有植物神经病变时或躯干迷走神经切除后,这种反应变得迟钝或明显减弱。由于植物神经系统中存在有烟碱受体,因此本文拟通过健康人胰岛素耐量实验(ITT);阿托品+ITT;及咪噻吩(Trimethophan)+ITT,观察它们对胰高血糖素释放作用的影响,进 It is known that insulin-induced hypoglycemia causes the islet alpha cells to release glucagon. Muscarinic receptor blocker atropine had no effect on this response. When diabetic patients with autonomic lesions or trunk vagotomy, the response becomes slow or significantly weakened. Due to the presence of nicotinic receptors in the autonomic nervous system, we investigated their effects on glucagon release by healthy human insulin tolerance test (ITT), atropine + ITT, and Trimethophan + ITT, Enter