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应用核酸分子杂交技术对28例口腔鳞癌组织中Rb、C—myc基因进行了研究，结果表明:鳞癌组织中6例出现Rb基因缺失、1例重排，分别占样本的21.4％和3．6％；12例出现C—myC基因扩增，1例重排，占样本的42．9％和3．6％，并且C—myc基因扩增与TNM分期有关。提示在口腔鳞癌中存在Rb抑癌基因失活和C—myc癌基因的激活，对鳞癌的发生、发展可能起着一定的作用。C—myc扩增可作为判断鳞癌预后的指标之一。
The results of Rb gene and C-myc gene in 28 cases of oral squamous cell carcinoma showed that there were 6 cases of Rb gene deletion and 1 case rearrangement in squamous cell carcinoma, accounting for 21.4% and 3 .6%; 12 cases of C-myC gene amplification, 1 case rearrangement, accounting for 42.9% and 3.6% of the sample, and C-myc gene amplification and TNM staging. It is suggested that inactivation of Rb tumor suppressor gene and C-myc oncogene in oral squamous cell carcinoma may play a role in the occurrence and development of squamous cell carcinoma. C-myc amplification can be used as a prognostic indicator of squamous cell carcinoma.