原发性巨球蛋白血症(Waldenstrm氏巨球蛋白血症)是属于慢性淋巴网状系统疾病。由于B淋巴细胞异常坛殖,产生了大量均一性异常蛋白-IgM型,并由此产生M蛋白血症以及多种临床变化。此病在国外屡见报道,但国内仍属罕见。本文报道原发性巨球蛋白血症并发冷球蛋白血症一例。 Primary macroglobulinemia (Waldenstrm’s macroglobulinemia) is a chronic lymphatic system disease. Due to the abnormal albuginea of ​​B lymphocytes, a large number of homozygous abnormal protein-IgM types are produced, and thus produce M-proteinase and a variety of clinical changes. The disease is frequently reported in foreign countries, but the country is still rare. This article reports a case of primary macroglobulinemia complicated with cryoglobulinemia.