目的:观察复方苦参注射液胸腔灌注治疗癌性胸腔积液的近期治疗效果。方法:癌性胸腔积液患者100例随机分为对照组及治疗组各50例。治疗组给予胸腔积液引流联合复方苦参注射液胸腔灌注治疗;对照组给予胸腔积液引流联合丝裂霉素胸腔灌注化疗,比较2组胸腔积液控制率、生活质量改善率、不良反应。结果:治疗组完全缓解16例,部分缓解12例,总有效率56%;对照组完全缓解15例,部分缓解14例,总有效率58%,2组比较差异无统计学意义(P>0.05)。2组治疗后生活质量有效率均为66%,2组比较差异无统计学意义(P>0.05)。治疗组不良反应发生率16%低于对照组56%(P<0.05)。结论:复方苦参注射液胸腔灌注治疗癌性胸腔积液较丝裂霉素不良反应轻。 Objective: To observe the short-term therapeutic effect of compound Kushen injection on pleural effusion for treating malignant pleural effusion. Methods: 100 patients with malignant pleural effusion were randomly divided into control group and treatment group, 50 cases each. The treatment group was treated by pleural effusion combined with compound Kushen injection. The control group was given pleural effusion combined with mitomycin by thoracic perfusion chemotherapy. The rate of pleural effusion control, quality of life improvement and adverse reactions in the two groups were compared. Results: In the treatment group, 16 cases were completely relieved, 12 cases partially relieved, and the total effective rate was 56%. In the control group, 15 cases were completely relieved, 14 cases partially relieved, and the total effective rate was 58%. There was no significant difference between the two groups (P> 0.05 ). The effective quality of life of the two groups after treatment was 66%, there was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the treatment group was 16% lower than 56% in the control group (P <0.05). Conclusion: The compound Kushen injection thoracic perfusion treatment of malignant pleural effusion than mitomycin adverse reaction.