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心肌自律性的变化,或由于形成兴奋折返回路,均可诱发 RIA。缺血和再灌时可引起一系列生化和离子变化,其中氧自由基的产生,在诱发 RIA 中的作用,目前已进行了大量实验研究。超氧阴离子(·O_2~-)和氢氧自由基(·OH)在缺血心肌再灌或再给氧时可大量产生。这些高反应能力的氧自由基可使心肌细胞膜脂质发生过氧化作用,引起膜的完整性、流动性和通透性的有害变化,从而导致心律失常。
Cardiac autonomic changes, or because of the formation of excitement reentry circuit, can induce RIA. Ischemia and reperfusion can cause a series of biochemical and ion changes, including the generation of oxygen free radicals in the role of induced RIA, a large number of experimental studies have been carried out. Superoxide anion (· O 2 ~ -) and hydroxyl free radicals (· OH) in ischemic myocardium reperfusion or reoxygenation can be produced in large quantities. These highly reactive oxygen radicals cause peroxidation of the myocardial cellular membrane lipids, causing deleterious changes in membrane integrity, fluidity and permeability leading to arrhythmias.