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目的通过检测冠心病患者和正常对照组血浆中网膜素-1和白介素-18(interleukin-18,IL-18)的水平,探讨血浆网膜素-1和IL-18的水平变化与冠心病发病的关系。方法选择2011年5月至11月住院患者74例(排除糖尿病等),分为冠心病组54例(其中不稳定型心绞痛组32例,稳定型心绞痛组22例)和对照组20例。于入院次日抽取空腹静脉血,采用酶联免疫吸附测定法(enzyme-linked immunosorbent assay,ELISA)测定血浆网膜素-1和IL-18水平,并测量身高、体质量、血压、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇等指标。结果冠心病组血浆网膜素-1水平较对照组低,两组差异有统计学意义(P<0.01),冠心病组血浆IL-18水平较对照组高,两组差异有统计学意义(P<0.05)。结论冠心病患者血浆网膜素-1水平下降和IL-18水平上升,可能在冠心病的发病机制中起一定作用。
Objective To detect the levels of plasma retinin-1 and interleukin-18 (IL-18) in patients with coronary heart disease (CHD) and normal controls, and to explore the relationship between plasma levels of retinulin-1 and IL-18 and coronary heart disease The relationship between the onset. Methods 74 inpatients (excluding diabetes) were selected from May to November 2011. They were divided into coronary heart disease group (54 cases), unstable angina group (32 cases), stable angina group (22 cases) and control group (20 cases). Fasting venous blood was drawn on the next day of admission, plasma levels of retinulin-1 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA), and height, body weight, blood pressure, fasting blood glucose, Total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol and other indicators. Results The level of plasma retinulin-1 in CHD group was lower than that in control group (P <0.01). The level of plasma IL-18 in CHD group was higher than that in control group (P <0.01) P <0.05). Conclusion The decrease of plasma retinulin-1 and the increase of IL-18 in patients with coronary heart disease may play a role in the pathogenesis of coronary heart disease.